Inflammatory Cell Distribution in Primary Merkel Cell Carcinoma

Inflammatory Cell Distribution in Primary Merkel Cell Carcinoma

Merkel cell carcinoma (MCC) is an aggressive poorly differentiated neuroendocrine cutaneous carcinoma associated with older age, immunodeficiency and Merkel cell polyomavirus (MCPyV) integrated within malignant cells. The presence of intra-tumoural CD8+ lymphocytes reportedly predicts better MCC-specific survival. In this study, the distribution of inflammatory cells and properties of CD8+ T ly...

Primary Cutaneous Neuroendocrine Carcinoma , Merkel Cell Carcinoma .

Prognostic Factors in Primary Merkel Cell Carcinoma

Finland Academic dissertation To be publicly discussed, with the permission of the medical Faculty of the University of This thesis is based on the following original articles, which are referred to in the text by their Roman numerals. Some unpublished data are also presented.

Tenascin-C in primary Merkel cell carcinoma.

BACKGROUND/AIMS Merkel cell carcinoma (MCC) is a rare malignant cutaneous neuroendocrine tumour that mostly affects the elderly. It shows rapid progression of the primary tumour, together with a vertical growth pattern into the underlying subcutaneous tissue. Metastatic dissemination to regional lymph nodes is early and frequent. Tenascin-C (Tn-C) is a large extracellular matrix glycoprotein th...

Merkel cell carcinoma and multiple primary cancers.

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumor of the skin for which causative factors remain largely unknown. The site-specific risks of multiple primary cancers associated with MCC, which may provide insight into etiologic influences, have not been quantified in large population-based studies. We estimated the long-term risk of subsequent primary tumors after a first primar...